Details

Project TitleImproved Drug Delivery Using Tough Hydrogel that Acts as a Synthetic Skin
Track Code2017-CAKM-67907
Websitehttp://otc-prf.org/
Short Description

Mukerrem Cakmak

Purdue Materials Engineering

Purdue Mechanical Engineering

Abstract
 
Tagsdrug delivery, Hydrogel, pharmaceuticals
 
Posted DateJul 31, 2017 10:59 AM

Researcher

Name
Mukerrem Cakmak
Gustavo Guzman
Siamak Shams Es-haghi

Improved Drug Delivery Using Tough Hydrogel that Acts as a Synthetic Skin

Background

For many years, the achievement of continuous release of medication has been the focus of controlled drug release research. An on-demand control of drug delivery is desired in many clinical situations, as it promises to improve therapeutic efficacy and lessen side effects. Hydrogels are an ideal candidates given they respond to changes in the environment including pH, temperature, light, electric fields, and magnetic fields. Unfortunately, such triggers to do not transfer to clinical environments well. There is a need for improved methods of delivering pharmaceutical drugs to patients.

Technology Summary

Purdue University researchers have developed the use of tough multiple-network hydrogels for the reliable delivery of water-soluble drugs dissolve in this medium.  The dissolved drugs are released from the hydrogel in a controlled fashion, suppressing the initial burst release of drugs and providing a reliable mechanism to controllably release drugs into a local area.  Some of the hydrogels utilized have similar mechanical properties to skin.  This provides greater comfort for a patient and allows for utilization in difficult applications areas like joints, e.g., knees, elbows.

Advantages

  • Compatible with water-soluble drugs
  • Controlled delivery of drugs
  • Suppresses initial burst release of drugs
  • Allows for stretching to large deformations
  • Mechanically similar to skin

Potential Applications

  • Pharmaceutical companies
  • Drug delivery
  • On-skin applications

Stage of Development

Concept validated through theory, simulation, or models

Web Links

For additional information, please contact otcip@prf.org.

Intellectual Property

Patent Number Issue Date Type Country of Filing
None None Provisional United States